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Thrombocythemia may lead to . Microvascular occlusions. Large vessel thrombosis . Bleeding. Microvascular occlusions involve small vessels of the distal extremtrombocitemie esentialaities (causing。

ET usually develops very slowly. It can affect people of any age. But it usually affects middle aged and older people. The average age at diagnosis is about 65 years although it can affect children and young adults.

In patients with suspected ET who lack JAK2 and MPL mutations, the exclusion of reactive causes is particularly important ().In studies of。

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